Jacques Monod: Fifty years after – Foreword

In Memoriam: Jacques Monod (1910–1976)

Jacques Monod, born 100 years ago, was one of the main founders of molecular biology. A quotation of Roger Stanier seems to me of immediate relevance to the topic of this meeting on ‘‘Chance and necessity in evolution,’’ dedicated to the works of Jacques Monod: ‘‘Jacques Monod, one of the great scientists of the twentieth century, will always have an honored place among the leaders of the secon...

Jacques Lucien Monod, 9 February 1910--31 May 1976.

Enzymatic cybernetics: an unpublished work by Jacques Monod.

In 1959, Jacques Monod wrote a manuscript entitled Cybernétique enzymatique [Enzymatic cybernetics]. Never published, this unpublished manuscript presents a synthesis of how Monod interpreted enzymatic adaptation just before the publication of the famous papers of the 1960s on the operon. In addition, Monod offers an example of a philosophy of biology immersed in scientific investigation. Monod...

Jacques Monod and Ernest Borek Editors of Microbes and Life

Allostery and the Monod-Wyman-Changeux model after 50 years.

The Monod-Wyman-Changeux (MWC) model was conceived in 1965 to account for the signal transduction and cooperative properties of bacterial regulatory enzymes and hemoglobin. It was soon extended to pharmacological receptors for neurotransmitters and other macromolecular entities involved in intracellular and intercellular communications. Five decades later, the two main hypotheses of the model a...